We develop unprecedented nano-delivery systems made of natural compounds such as green tea catechin and melatonin (a sleeping hormone in the brain), that can treat various intractable diseases and aging-related damages to overcome the limitations of current treatment. (Fig. 1). The unique nanosytems can deliver various types of drugs such as proteins, peptides, small molecules, and nucleic acids with high concentrations in a targeted manner to the disease sites of tumors, the brain, the posterior eye segment, etc. where drug delivery seriously is limited due to complicate  multiple biological barriers. The nanosystems enable reducing the adverse effect (one of major problems of conventional drug treatment), amplifying drug efficacy through synergistic effects due to the intrinsic therapeutic efficacy derived from green tea catechin and melatonin, in addition, overcoming drug resistance which is developed by most drugs.

Nature-inspired nanoparticles to fight intractable diseases and aging